Journal article
The infarct core is well represented by the acute diffusion lesion: Sustained reversal is infrequent
BCV Campbell, A Purushotham, S Christensen, PM Desmond, Y Nagakane, MW Parsons, MG Lansberg, M Mlynash, M Straka, DA De Silva, JM Olivot, R Bammer, GW Albers, GA Donnan, SM Davis
Journal of Cerebral Blood Flow and Metabolism | SAGE PUBLICATIONS INC | Published : 2012
Abstract
Diffusion-weighted imaging (DWI) is commonly used to assess irreversibly infarcted tissue but its accuracy is challenged by reports of diffusion lesion reversal (DLR). We investigated the frequency and implications for mismatch classification of DLR using imaging from the EPITHET (Echoplanar Imaging Thrombolytic Evaluation Trial) and DEFUSE (Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution) studies. In 119 patients (83 treated with IV tissue plasminogen activator), follow-up images were coregistered to acute diffusion images and the lesions manually outlined to their maximal visual extent in diffusion space. Diffusion lesion reversal was defined as voxels of acut..
View full abstractGrants
Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
The EPITHET study was supported by the National Health and Medical Research Council of Australia, National Stroke Foundation and National Heart Foundation of Australia. The DEFUSE study was funded by National Institutes of Health (NIH) Grants RO1 NS39325, Principal Investigator, Gregory W Albers; K24 NS044848, Principal Investigator, Gregory W Albers; K23 NS051372, Principal Investigator Maarten G Lansberg and the RAPID software development was supported by R01 EB002711, Principal Investigator, Roland Bammer. Bruce Campbell is supported by the National Health and Medical Research Council of Australia Postgraduate Scholarship 567156, the Heart Foundation of Australia, a Cardiovascular Lipid (CVL) Australia grant and the Neuroscience Foundation of the Royal Melbourne Hospital.